منابع مشابه
Kinetics of reprogramming in cell fusion hybrids.
Somatic cells can obtain pluripotency by fusion with pluripotent stem cells. The resulting fusion hybrids display pluripotential characteristics, such as inactivation of tissue-specific genes, differentiation potential to all three germ layers, and a specific epigenetic state corresponding to the pluripotent cells. However, the fusion hybrid cells are not identical to the pluripotent fusion par...
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Establishment of totipotency after somatic cell nuclear transfer (NT) requires not only reprogramming of gene expression, but also conversion of the cell cycle from quiescence to the precisely timed sequence of embryonic cleavage. Inadequate adaptation of the somatic nucleus to the embryonic cell cycle regime may lay the foundation for NT embryo failure and their reported lower cell counts. We ...
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Cell reprogramming is a process of transitions from differentiated to pluripotent cell states via transient intermediate states. Within the epigenetic landscape framework, such a process is regarded as a sequence of transitions among basins on the landscape; therefore, theoretical construction of a model landscape which exhibits experimentally consistent dynamics can provide clues to understand...
متن کاملA Proposed Quantitative Index for Assessing the Potential Contribution of Reprogramming to Cancer Stem Cell Kinetics
Enrichment of cancer stem cells (CSCs) is thought to be responsible for glioblastoma multiforme (GBM) recurrence after radiation therapy. Simulation results from our agent-based cellular automata model reveal that the enrichment of CSCs may result either from an increased symmetric self-renewal division rate of CSCs or a reprogramming of non-stem cancer cells (CCs) to a stem cell state. Based o...
متن کاملNuclear reprogramming.
There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and pa...
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ژورنال
عنوان ژورنال: Nature Reports Stem Cells
سال: 2008
ISSN: 1754-8705
DOI: 10.1038/stemcells.2008.36